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The current study was performed with the approval of the Ethics Committee of The First Affiliated Hospital of Harbin Medical University. All animal experiments were performed in strict accordance with the relevant provisions of the Guiding Opinions on Treating Experimental Animals of the Ministry of Science and Technology of the People’s Republic of China, and conformed to the recommendations in the Guide for the Care and Use of Laboratory Animals published by the US National Institutes of Health. Extensive efforts were made to minimize the number and suffering of the experimental animals.

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