APPswe/PS1dE9 (APP/PS1) double transgenic mice were purchased from Jackson Laboratory (No. 005864, Bar Harbor, ME, USA). Breeding was conducted using female transgenic mice and their male wild-type siblings. Mice were maintained under a 12 h/12 h light/dark cycle in constant conditions of temperature (24 °C) and humidity (55–65%) with free access to food and water. All procedures were approved by the Institutional Animal Care and Use Committee at the National Research Institute of Chinese Medicine (IACUC No.:105-417-1).
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