Data resources

The Inflammation and Host Response to Injury, Large Scale Collaborative Research Program has completed multiple studies on the genomic responses to systemic inflammation in patients and human volunteers as well as murine disease models (18,20–23). These datasets include genome-wide expression analysis on white blood cells obtained from serial blood draws in 167 patients up to 28 days after severe blunt trauma (20), 244 patients up to 1 year after burn injury, and 10 healthy humans for 24 h after administration of low-dose bacterial endotoxin (18), as well as expression analysis on analogous samples from well-established mouse models of trauma, burns and endotoxemia (16 treated and 16 controls per model) (21–23). In order to systematically compare the similarities and differences in gene response between patients and murine models in different human inflammatory diseases, we further sought and evaluated additional well curated studies of patients and corresponding mouse models from Gene Expression Omnibus (GEO) (24) for several other severe acute inflammatory diseases [sepsis, acute respiratory distress syndrome (ARDS) and infections], and integrated these datasets in KERIS. The biological findings from the comparisons have been published (5). All the gene expression datasets in KERIS have been deposited in GEO under the accession numbers listed in Table ​Table11.

The baseline gene expression data were calculated based on the RNA-seq data of 13 paired mouse-human samples under one experimental protocol generated by Lin et al. (14) The 13 tissues include, SB: small bowel, SG: sigmoid, SX: spleen, LG: lung, LR: liver, BR: brain, OV: ovary, TT: testis, PA: pancreas, AD: adrenal, HE: heart, FT: fat, and KD: kidney.