As described previously21,23, two different approximations of D and f were calculated from signal intensities S(b) and S(0) of the acquired b-values, one from b0 = 0, b1 = 50, b3 = 800 and one from b0 = 0, b2 = 250, b3 = 800 s/mm2:
From the four b-values, D* was approximated by using D2′ and f2′ and the reading for b1:
D*′ cannot be determined for all voxels, because some voxels are not affected by perfusion. Voxels with not defined values were excluded from ROI analysis.
Moreover, the conventional ADC was calculated:
Parameter maps and ROI analyses were calculated offline using custom written software in MATLAB (MathWorks, Natick, MA).
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