Study Population and Ethics

We retrospectively included all the consecutive patients diagnosed with CTRCD in the two tertiary hospitals in Spain: Clínica Universidad de Navarra between 2000 and 2011 and Hospital Universitari de Bellvitge between 2010 and 2016. The patients with cancer were referred to the cardiology units by the oncologists or hematologists to evaluate and treat cardiotoxicity before implementing the cardio-oncology units in these centers. The LVSD was defined as LVEF < 50%, with a previously normal value, after cancer treatment administration, such as chemotherapy and targeted therapies, such as immunotherapy. The patients with baseline cardiac function not available or those with a previous history of LVSD were excluded. The study complied with the Declaration of Helsinki, and all the patients gave consent for using their data for research purposes.