2.1. Data collection

DIP and DEP data for SARS-CoV and SARS-CoV-2 were obtained from Stukalov et al. [4]. In brief, this study [4] used A549 human lung carcinoma cells infected with SARS-CoV or SARS-CoV-2 and 6, 12 and 24 hours after infection mass spectrometry analyses were used to investigate virus–host interactions and changes in protein expression. We used the high-confidence virus–host interactions identified after infection as DIP for SARS-CoV (521 proteins) and SARS-CoV-2 (781 proteins). As alterations in protein expression levels were most evident at 24 hours after infection (hpi; Bayesian linear model-based unadjusted two-sided P-value ≤10−3, |log2 fold change| ≥0.5), we used the published data from this time point as DEPs for SARS-CoV (188 proteins) and SARS-CoV-2 (197 proteins).