Principal component analysis for differentiating brain cell-types

A matrix representing the metabolic function scores for 3 brain cell types (i.e., astrocytes, neurons and oligodendrocytes) was constructed by multiplying the metabolic task scores computed in their continuous version (Table S4) with the ones in their binary version (Table S5). A PCA analysis on this matrix was conducted. As this analysis did not enable the differentiation between astrocytes and oligodendrocytes, we performed a subsequent similar PCA analysis by only using the samples related to these specific cell-types.