Curation of metabolic tasks

The curation was done by first taking the union of previously published lists of metabolic tasks (Blais et al., 2017; Thiele et al., 2013). We removed duplicated tasks and lumped tasks that rely on the description of similar metabolic functions. Each remaining task without strong biological evidence was removed. We also created 9 new tasks that were essential for the acquisition of already described metabolic functions (i.e., intermediate biosynthetic steps for the acquisition of other tasks). Doing so, we obtained a collection of 195 tasks associated with 7 systems (energy, nucleotide, carbohydrates, amino acid, lipid, vitamin & cofactor and glycan metabolism). For each task, we provided its original source (Recon and/or iHsa) and comments on the biological evidence of this metabolic function (Table S1).