5.7. Effect of the Lead Compound (OX11) on Resistant Bacterial Strains

Based on the above pharmacological investigations, OX11 was found to be the promising antibacterial agent among all the tested compounds. The MIC of OX11 was determined against 19 different environmental isolates of E. coli, two strains of K. pneumoniae, and one strain each of Acinetobacter sp., K. georgiana, and C. werkmanii.(30,31) These environmental isolates were taken from the River Yamuna Delhi stretch (India) and drain effluent water of the Ghazipur Slaughter House (India). Some of these environmental isolates are multidrug resistant (MDR) phenotypes. Details of their resistance pattern against different antibiotics are given in Table 8. The studies on the synergistic effect (with AMP and sulfamethoxazole) were performed using a previously mentioned protocol.⁵¹ Because of the structural similarities with OX11, we included the sulfamethoxazole (SMX) antibiotic in our study on resistant strains for comparison.