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2.10. Establishment of adjuvant-induced arthritis (AIA) rat model
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The arthritis model was induced using a complete freund adjuvant (CFA, containing 10 mg/ml of mycobacterium tuberculosis) [32,33]. Briefly, 50 µl CFA was subcutaneously injected into the paws of SD rats at Day 1. The swelling of the rat limbs was monitored every day. All animals were housed in standard condition that met the requirements of the animal ethics committee.
Copyright and License information: ©2021 Shenyang Pharmaceutical University. Published by Elsevier B.V.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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