The use of MCPI to control pain following TKA has gained wide acceptance [8–10]. The agents mostly used in MCPI typically include corticosteroids, local anesthetics, opioids, and nonsteroidal anti-inflammatory drugs (NSAIDs) [11]. Corticosteroids are believed to be a key component owing to their local anti-inflammatory effects and their ability to reduce the local stress response to surgery [12]. However, there is conflicting evidence regarding its benefits regarding MCPI usage. In this study, participants will be randomly assigned to one of the three groups receiving a high dose of betamethasone MCPI, normal dose of betamethasone MCPI, and non-betamethasone MCPI groups.
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