P7C3-A20 treatments

All mice were single-housed for the duration of treatment. Forebrain-Ca_v1.2 cKO and wild-type littermate mice received 10 mg/kg P7C3-A20 or vehicle (5% DMSO, 20% cremaphor in 5% dextrose), intraperitoneally, twice a day for 30 d, starting at P21. This dose of P7C3-A20 was chosen based on efficacy in multiple animal models of neuroprotection (De Jesus-Cortés et al., 2012; Tesla et al., 2012; Yin et al., 2014). Mice were transcardially perfused with 4% PFA 24 h after the last BrdU injection. In separate experiments, brains were flash frozen and processed for BDNF ELISA.