Retrospective analysis of ORR and duration of treatment with afatinib

Response to afatinib and duration of afatinib treatment was tabulated from 803 patients in the Uncommon EGFR Database (www.uncommonegfrmutations.com). Objective response rate was reported in 529 patients. Patients were stratified by either structure–function-based groups or exon-based groups and ORR was determined by counting the number of patients reported to have complete response or partial response. Fisher’s exact test was used to determined statistical differences between subgroups (structure based or exon-based). Duration of treatment was provided in the Uncommon EGFR Database for 746 patients. Patients were stratified by structure–function-based groups and exon-based groups and median DOT was calculated using the Kaplan–Meier method. Statistical differences in Kaplan–Meier plots, HR and P values were generated using GraphPad Prism software and the Mantel–Cox log-rank method. When mutations were not explicitly stated (that is, exon 19 mutation) those patients were excluded from the structure–function-based analysis but included in the exon-based analysis.