2.2. Database Identification and Selection

Search queries for original research reports were run in PubMed/MEDLINE, EMBASE, and Yale University’s TRIP Medical Database in April 2021 by one author (R.M.H-S.) using Boolean strings with both MeSH and general terms. When available, filters were used to identify human studies as well as systematic literature reviews that captured human studies focused on our PICO. Specifically, our search strategy (available from the authors on request) was adapted to each database, using terms focused on PROs and/or PROMs: PRO-related terms (e.g., anxiety, genetic testing, function, satisfaction, experience, education, psychology, privacy, knowledge, attitude, insurance coverage, healthcare expenditures/cost, cost-sharing, treatment/surveillance adherence); genetic testing (clinical or direct-to-consumer with a clinical intermediary); and breast and ovarian cancer syndrome, Lynch syndrome, and/or FH. The reference lists of relevant systematic literature reviews were also examined.