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2.5.4. In Vitro Dissolution Test

MC Myung-Hee Chun
JK Ji Yeon Kim
EP Eun-Seok Park
DC Du Hyung Choi
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Dissolution tests were conducted using a bilayer tablet. Dissolution tests were conducted according to the USP Apparatus 1 guidelines (Basket Apparatus) (ERWEKA GmbH) with 1000 mL of phosphate buffer (pH 6.8) as dissolution medium, maintained at 37 ± 0.5 °C, and a basket rotation speed of 100 rpm. Four tablets from each formulation were tested in each experiment. Sample aliquots (5 mL) were withdrawn at sampling time and filtered through a 0.45 µm membrane filter.

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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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