Improve Research Reproducibility A Bio-protocol resource
Concise Method
tooltip

3.6.2. Ethyl Hydrogen Benzylphosphonate (3b)

DT Damian Trzepizur
AB Anna Brodzka
DK Dominik Koszelewski
RO Ryszard Ostaszewski
request Request a Protocol
ask Ask a question
Favorite

The synthesis of 3b was conducted according to Section 3.5, with the only difference being that the reaction time was extended to 48 h. Yield: 76%; 1H NMR and 31P NMR spectra were in accordance with previous literature reports [43]; pale yellow oil; 1H NMR (400 MHz, DMSO-d6) δ 7.51–7.15 (m, 5H; broad -OH, 1H), 3.93–3.84 (m, 2H), 3.06 (d, JH-P = 21.4 Hz, 2H), 1.15 (t, JH-H = 7.1 Hz, 3H); 13C NMR (101 MHz, DMSO-d6) δ 133.4 (d, JC-P = 8.9 Hz), 129.7 (d, JC-P = 6.4 Hz), 128.1 (d, JC-P = 2.7 Hz), 126.1 (d, JC-P = 3.4 Hz), 60.5 (d, JC-P = 6.0 Hz), 33.6 (d, JC-P = 133.6 Hz), 16.3 (d, JC-P = 6.0 Hz); 31P NMR (162 MHz, DMSO-d6) δ 23.3.

Copyright and License information:  ©2021 by the authors.
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

Do you have any questions about this protocol?

Post your question to gather feedback from the community. We will also invite the authors of this article to respond.

post Post a Question
0 Q&A