Statistical analysis

SPSS 21.0 (SPSS, Inc, Chicago, IL, USA) was used for statistical analyses of the data in this study. Measurement data are expressed as the mean ± standard deviation. Comparison between OC tissues and tumor-adjacent tissues was performed by a paired t test. Data comparison between two groups was performed by an unpaired t test, with data comparison between multiple groups performed with one-way analysis of variance (ANOVA) followed by Tukey’s post hoc test. The OD values and the tumor volumes at different time points were compared with two-way ANOVA followed by Bonferroni’s post hoc test. Pearson correlation was employed to analyze the relationship between the two indicators. The survival rate of the patients was calculated with the Kaplan-Meier method, and the log-rank test was applied for univariate analysis. p < 0.05 was considered to be indicative of statistical significance.