Ethics statement

The study protocol was performed with the approval of the Ethics Committee of The Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiaotong University and in line with the Declaration of Helsinki. All patients and/or legal guardians provided signed informed consent documentation prior to enrollment into the study. All animal experiments were performed with the approval of the Animal Ethics Committee of The Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiaotong University for medical research purposes. Extensive efforts were made to ensure minimal animal number use as well as suffering and pain inflicted.