2.6. The main endpoints

The primary outcome was MAKE30. The second outcomes included 30-day mortality, ICU mortality, In-hospital mortality, ICU length of stay, hospital length of stay, creatinine highest before discharge(mg/dl) and needs for RRT. MAKE30 was defined as the composite of death, new receipt of renal-replacement therapy, or persistent renal dysfunction (final inpatient creatinine value ≥200% of the baseline value) within 30 days after enrollment.

In this study, we conducted subgroup analysis according to the age in order to investigate the comparison between children and adults. Those children were defined as patients who received treatment in pediatric intensive care units (PICU), adults were defined as patients who received treatment in adult ICU.