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Statistical analyses were performed using IBM SPSS ver. 21 (IBM Corp., Armonk, NY, USA). When comparing clinical features of patients with and without proliferative lesions, we used the Mann-Whitney test for unpaired values and Fisher's exact test for non-numeric data. Mean scores at each time point following treatment in both groups were compared using the Mann-Whitney test. p-values less than 0.05 were considered statistically significant.
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