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The tumor cells were injected subcutaneously into the backs of 4–5-week-old female Balb/c nude mice. The xenograft tumor size was measured every 3 days and the tumor volume was determined as (lengthxwidth2)/2. When tumors grew to 50 mm3, mice were randomized to the following groups: vehicle (DMSO), gefitinib (5 mg/kg), or N19 (5 mg/kg). Drugs were administered by intraperitoneal injection every 3 days.
Copyright and License information: ©2016 Macmillan Publishers Limited
Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
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