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Histone ChIP-seq data were downloaded and mapped into the reference genome by Bowtie54. Then, MACS255 was used for peak calling with default parameters (P < 0.00001, mfold > 10). In addition, H3K27ac and H3K4me1 peaks were combined for defining putative enhancer regions. The rate of gene-body region overlapped by each histone mark was calculated as follow.

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