Determination of in vivo clearance and DAO antigen and activity

EG Elisabeth Gludovacz
KS Kornelia Schuetzenberger
MR Marlene Resch
KT Katharina Tillmann
KP Karin Petroczi
MS Markus Schosserer
SV Sigrid Vondra
SV Serhii Vakal
GK Gerald Klanert
JP Jürgen Pollheimer
TS Tiina A Salminen
BJ Bernd Jilma
NB Nicole Borth
TB Thomas Boehm
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rhDAO-WT and the different mutants were administered to rats and mice as described (Gludovacz et al., 2020). DAO antigen concentrations and enzymatic activity were measured in duplicate as published (Boehm et al., 2020; Boehm et al., 2017). The activity curve in the linear range was used to calculate the slope corresponding to the oxidation rate.

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