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Personalized EPPI risk score and gene expression heat maps

SL Su Bin LIM
ST Swee Jin TAN
WL Wan-Teck LIM
CL Chwee Teck LIM
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The regression coefficient of each EPPI gene was derived from 489 early-stage NSCLC patients who had complete survival information from the initial discovery set. The EPPI risk score was calculated as a sum of multiplication of the expression level of each EPPI gene and its respective Cox regression coefficient identified from the discovery set (EPPI risk score = 29+∑ (expression level of gene) X (Cox regression coefficient)). Each Cox regression coefficient used for EPPI risk score computation is shown in Supplementary Table 3. A constant was added to ensure all scores are positive. The risk score generated for each patient in the discovery set was visualized with a personalized two-dimensional heatmap using Gene-E open software (Broad Institute).

Copyright and License information: The Author(s) ©2017
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