We will search the electronic databases of EMBASE, MEDLINE and the Cochrane Central Registry of Controlled Trials (CENTRAL), from their inception until 26 January 2016. Our search will be limited to reports published in English. Further, we will search the WHO clinical trial registry (http://apps.who.int/trialsearch/Default.aspx), and clinical trial registry (https://clinicaltrials.gov/), to look for any registered studies, which fulfil our eligibility criteria and crosscheck for their published results. Unpublished, but completed study results will be requested from the authors or investigators. To further ensure comprehensiveness, we will review the bibliographies of recent reviews and selected studies.
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