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Anti-ACE910 antibodies (anti-drug antibodies [ADAs]) in plasma were detected by an electro-chemiluminescence immunoassay using a validated method according to US Food and Drug Administration guidance.20 For ADA-positive samples, an immunoglobulin E (IgE) antibody test was conducted using Phadia ImmunoCAP kit (Thermo Fisher Scientific Inc.). ADA-positive subjects were defined as any subject with at least 1 ADA-positive plasma sample.
Copyright and License information: ©2016 by The American Society of Hematology
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