Experimental model chronic unpredictable mild stress (CUMS)

LQ Leticia R. Quesnel-Galván
PT Patricia V. Torres-Durán
DE David Elías-Viñas
LV Leticia Verdugo-Díaz
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CUMS model consisted of applying a different kind of mild stressor each day for 21 days [18]. The stressors were: movement restriction for 2 h, 4 °C temperature exposure, the combination of both, forced swimming for 15 min, 45° cage tilting for 2 h, food deprivation for 24 h, water deprivation for 18 h, and isolation for 48 h. These were applied in a random form.

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