Animals

All procedures conformed to the national guidelines of the Swiss Federal act on animal protection and were approved by the Cantonal Veterinary Office Zurich (Permit Number: 18-2014). All procedures fulfill the ARRIVE guidelines on reporting animal experiments. Male C57BL/6J mice (Janvier, France), weighing 20–25 g, of 8–10 weeks of age were used. Animals were housed in a temperature controlled room in individually ventilated cages, under a 12-h dark/light cycle. Paper tissue was given as environmental enrichment. Access to pelleted food (3437PXL15, CARGILL) and water were provided ad libitum.