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Enrichment analysis using gene ontology and network analysis

JJ Jae Hun Jung
YJ Yong Woo Ji
HH Ho Sik Hwang
JO Jae Won Oh
HK Hyun Chang Kim
HL Hyung Keun Lee
KK Kwang Pyo Kim
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A gene ontology (GO) search was performed to explore the biological processes and cellular components in TF and LF associated with DED. KEGG pathway mapping was also performed using DAVID freeware49. GO biological processes enriched by the DEPs were identified as those with a p-value < 0.05. To construct a network depicting the enriched processes, we selected DEPs involved in enriched biological processes. To reconstruct the network model for DEPs, we collected protein-protein interactome information from the STRING 9.1 public database50. The network model was built with sorted DEPs and interactome data using Cytoscape.

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