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Patient-derived xenograft (PDX) models
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Three patient-derived xenograft models (COGN-424X, COGN-557X, and COGN603X) were obtained from the Children’s Oncology Group’s (COG) Childhood Cancer Repository. Written informed consent and IRB approval was obtained according to COG protocols and studies were conducted in accordance with recognized ethical guidelines. Models were propagated in mice and tumors were flash frozen before gDNA or protein was extracted.
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