Allelic dosage of HLA-DRB1*15 and HLA-A*02 were obtained by imputation of HLA types from SNP genotypes in the MHC region using the HLA*IMP:02 program (34). The genotypes were generated using the Illumina Human Quad 660 chip, the Immunochip custom array, or both. Genotyping was carried out in previous studies analyzing the genetic risk of MS for the individuals included in this study (35, 36). Only HLA genotypes with a quality score above 0.7 were included.
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