Image-data acquisition

Participants were trained to lie still in a mock scanner 30 minutes before imaging. A person with expertise in image-data analysis oversaw the scan sessions and inspected the raw DWI data for visible motion immediately after scanning. In cases of excessive motion (4.1% of the initial sample), the scan was repeated either in the same or a different session. This process ensured that all raw DW-images were free of visible motion (details in Supplement 1).

A whole-head, high-resolution T1-weighted multi-echo MP-RAGE anatomical volume was acquired. TR = 2530 ms, TE = 1640 ms, TI= 1400 ms, flip angle =7°, FOV= 220×220, interleaved slice number = 176 slices, slice thickness = 1 mm, in-plane resolution = 1.0 mm².

TR = 9300 ms, TE = 84 ms, TI = 2500 ms, flip angle = 90°, FOV= 256×256, in-plane resolution = 2.0 mm², slice thickness = 2 mm, 10 baseline volumes (b=0) and 30 diffusion-weighted volumes (b = 700 s/mm²) with 74 slices per volume.