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All statistical analyses were carried out using GraphPad Prism version 6.00 for Windows (GraphPad Software, San Diego California USA). One-way ANOVA using a Kruskall-Wallis test was used to compare the differences among groups, with a confidence interval of 95% for all experiments. Bonferroni post-test was used for individual comparison between groups. For survival experiments, differences among groups were analyzed by Kaplan-Meier estimator.
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