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Kinetic Analysis of the Drug Release Data

AM Amir Maghrabia
MB Mariza Boughdady
MM Mahasen Meshali
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In vitro release data were analyzed using linear regression equations of zero-order, first-order diffusion-controlled release mechanism,34 Higuchi’s model,35 and Korsmeyer–Peppas kinetic model to determine the kinetics and the mechanism of the drug release.36 The highest coefficient of determination (R2) model was deemed to depict the drug release mechanism.

To investigate the pharmacokinetics of the optimized formula, F2- NPs were loaded in an enteric-coated hard gelatin capsule. This enteric-coated dosage form would facilitate NPs administration and protect CTX from the hostile environment of the stomach as well.

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