Statistical analysis

All values are presented as means ± SEM. All statistical analyses were performed with the GraphPad Prism software (version 6.0, La Jolla, CA, USA). Considering that the variance homogeneity was not certain due to the effective equal to or less than 10 mice/group, statistical comparisons between two or more groups were performed using Kruskal-Wallis test (ordinary one-way ANOVA) followed by post-hoc analysis with Dunn’s test to compare controls (C57BL/6J) to FVB mice. To assess the correlation between two quantitative values, non-parametric Pearson correlations were performed (not being able to ensure that the data followed a Normal distribution). P <0.05 was considered as statistically significant.