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This study was an adaptive-design, randomized, multicenter, double-blind, placebo-controlled trial. The trial protocol23 was approved by the central institutional review board from Chinese PLA General Hospital (IRB No. [2012] Pharmaceutical (025)). This trial complied with the principles of the Declaration of Helsinki. Informed written consent was obtained from all participants. Patients or the public were not involved in the design, or conduct, or reporting, or dissemination plans of our research.
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