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The validated Spanish version of the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was administered starting at the 48-month visit. Ever wheeze was determined based on caregiver report of “Has your child ever had wheezing or whistling in the chest at any time in the past?” and current wheeze was defined based on response to “Has your child had wheezing or whistling of the chest in the past 12 months?”
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