Validated candidate circRNAs were used as seeds to enrich a circRNA-miRNA-gene network according to the analysis of TargetScan (http://www.targetscan.org/) combined with miRanda (http://www.microrna.org/). Cytoscape (http://www.cytoscape.org/) was applied to build a circRNA–miRNA–mRNA interaction network of hsa_circ_0005075. The predicted gene functions in the networks were annotated using GO and KEGG pathway analysis.
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