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2.7. Construction of circRNA-miRNA-TF-mRNA Interaction Network
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The Cytoscape (version 3.8.2) software was used to map the circRNA-miRNA-TF-mRNA regulatory network. The MCODE plugin (degree cutoff = 2, node score cutoff = 0.2, k − core = 2, and max.depth = 100) was also applied in the establishment of core genes and subnetworks in the network. Based on their enrichment scores, the top two core subnetworks were selected for presentation and subsequent analysis based on their enrichment scores.
Copyright and License information: ©2021 Jin Huang et al.
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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