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VV Vejay N. Vakharia
RR Roman Rodionov
AM Anna Miserocchi
AM Andrew W. McEvoy
AO Aidan O’Keeffe
AG Alejandro Granados
SS Shahrzad Shapoori
RS Rachel Sparks
SO Sebastien Ourselin
JD John S. Duncan
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We included patients with drug-refractory focal epilepsy, due to undergo SEEG implantation as part of their pre-surgical evaluation, aged between 18–80 years and able to provide informed consent.

Exclusion criteria included pregnancy, uncorrectable coagulopathy, lack of capacity to consent and patients deemed unfit for general anaesthesia. Following a multi-disciplinary team discussion, all patients were given a patient information sheet before providing written informed consent. Written informed consent was taken by a delegated member of the research team and combined with a pre-operative hospital visit for digital subtraction angiography, 2–6 weeks before implantation. Patients were considered enrolled in the trial once randomised using Sealed Envelope.

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