Analysis of primary outcome

MK Maki Kawasaki
AM Asako Mito
MW Masako Waguri
YS Yuichi Sato
EA Emiko Abe
MS Mayumi Shimada
SF Sayuri Fukuda
YS Yuki Sasaki
KF Kei Fujikawa
TS Takashi Sugiyama
EO Erika Ota
JN Jin Nakazawa
TO Tadashi Okoshi
HT Hidemi Takimoto
YH Yuka Honda
EI Eisuke Inoue
YH Yuji Hiramatsu
NA Naoko Arata
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Change in weight at each measurement point will be analyzed by fitting a mixed-effects model for repeated measures. The explanatory variables of the model include the pre-pregnancy body weight, measurement time points, intervention group, and interaction between measurement time points and intervention group. The variance structure is unstructured (variance at each time point is heterogenous). Using this model, the least mean square of the rate of change in body weight at 12 months postpartum and its 95% confidence interval are estimated for each group, and differences between the groups are compared using t-tests (two-sided). The significance level of the test is set at 0.05.

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