Analysis of dynamic molecular interaction networks during NAFLD progression

JZ Jing Zheng
HW Huizhong Wu
ZZ Zhiying Zhang
SY Songqiang Yao
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To analysis the key genes involved in the NAFLD progression, dynamic molecular interaction networks were constructed using DyNet (1.0.0) application in Cytoscape (3.6.1). DEGs were input into the STRING database to construct the protein–protein interaction (PPI) network, and DyNet [11] was applied to analyze the most ‘rewired’ nodes across dynamic network states. To analyze the heterogeneous mechanism of NAFLD, the rewired nodes from obese and non-obese NALFD progression sequences were intersected and subsequently enriched by KEGG within the R package clusterProfiler [9]. Node degree variance was calculated by DyNet and was displayed as Dn-Score.

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