(1) The number and proportion of the study patients who initiated medication with the study medicines before and after September 2017 in different demographic, social and economic characteristics and tumour progression stage sub-groups, were calculated for descriptive analyses;
(2) The monthly proportion of patients who initiated medication with the study medicines before and after September 2017 = monthly number of the study patients who initiated medication with the study medicines / total number of the study patients * 100 %, was used for longitudinal analyses;
(3) Medication choice was defined as “1” for the patients who initiated treatment with the study medicines; “0” for the patients who initiated treatment without the study medicines, was used for the binary logistic regression analyses.
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