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Gene set enrichment analysis (GSEA) was performed using the clusterProfiler R package (version 3.16.0)33 and the ReactomePA R package (version 1.32.0)34 for GO-BP (Gene Ontology - Biological Process), KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways and Reactome pathways. P-values were corrected with the Benjamini-Hochberg (BH) method. A BH-adjusted P < 0.05 was considered to be significant.
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