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2.4. MRI scans

SI Silvia Ingala
CB Casper De Boer
LM Larissa A Masselink
IV Ilaria Vergari
LL Luigi Lorenzini
KB Kaj Blennow
GC Gaël Chételat
CP Carol Di Perri
ME Michael Ewers
WF Wiesje M van der Flier
NF Nick C Fox
JG Juan Domingo Gispert
SH Sven Haller
JM José Luís Molinuevo
GM Graciela Muniz‐Terrera
HM Henri JMM Mutsaerts
CR Craig W Ritchie
KR Karen Ritchie
MS Mark Schmidt
AS Adam J Schwarz
LV Lisa Vermunt
AW Adam D Waldman
JW Joanna Wardlaw
AW Alle Meije Wink
RW Robin Wolz
VW Viktor Wottschel
PS Philip Scheltens
PV Pieter Jelle Visser
FB Frederik Barkhof
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Brain MRI scans were performed with standardized acquisition protocols, including 3D‐T1, 3D‐FLAIR, 2D‐T2, and 2D‐T2* sequences. The images were centrally evaluated by experienced raters, blind to the clinical and neuropsychological data. Visual assessment of the scans included white matter hyperintensities,28, 29 perivascular spaces (PVS),30, 31 microbleeds (CMBs),30 medial temporal lobe atrophy (MTA),32 and posterior cortical atrophy (PCA;33 supporting information). Regional gray matter volumes were determined on 3D‐T1 weighted images using a segmentation process based on atlas‐propagation with the Learning Embeddings for Atlas Propagation (LEAP) framework.34

Copyright and License information:  ©2021 The Authors. published by Wiley Periodicals, LLC on behalf of Alzheimer's Association
This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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