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2.6. The PPI network construction and hub genes identification

XS Xueying Shi
SX Shilin Xia
YC Yingming Chu
NY Nan Yang
JZ Jingyuan Zheng
QC Qianyi Chen
ZF Zeng Fen
YJ Yuankuan Jiang
SF Shifeng Fang
JL Jingrong Lin
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Search Tool for the Retrieval of Interacting Genes (STRING, https://string-db.org/) database (v11.0), an online biological database designed for predicting protein-protein interaction (PPI) networks, was used to analyze an interactive relationship among DEGs. A combined score>0.4 was selected as significant. CytoHubba, a pluggable unit of Cytoscape (v3.7.2), was used to visualize the PPI network and calculate the Maximal Clique Centrality (MCC) [21, 22]. The eight genes with top highest MCC was identified as hub genes.

Copyright and License information:  ©2021 Shi et al
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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