Data presentation and statistical analysis

All experimental data and statistical analysis were performed using the GraphPad Prism program (GraphPad Prism, version 5.0 for Windows; GraphPad Software, Inc; San Diego, CA). Data were expressed as mean values ± standard error of the mean (SEM). To assess statistical differences, data were analyzed using Student unpaired 2-tailed Student t test. ECM clinical scoring data were assessed by 2-way analysis of variance. Finally, mouse survival data were compared using a log-rank (Mantel-Cox) test. For all statistical tests, P values <.05 were considered significant.