CCLE data analysis

Gene expression data for the CCLE lines were obtained from DepMap 19Q1 DepMap release (www. DepMap.org). A ssGSEA signature (Subramanian et al, 2005) score was calculated for the Hallmark_TNFA_signaling_via_NF‐κB gene set. Aneuploidy scores were obtained from Ref.(Cohen‐Sharir et al.). The association between the signature score and the aneuploidy groups was assessed by linear regression analysis, using the R package limma (Ritchie et al, 2015). Significance was calculated by empirical Bayes‐moderated t‐statistics.