The Kaplan-Meier survival curves were plotted with GraphPad Prism 8 (GraphPad Software, San Diego, CA) and the P values were calculated using the log-rank test. The two-sided Kolmogorov-Smirnov test was performed for the empirical cumulative density function (ECDF) curves and the P values were provided in pausing index analysis. For all other analyses, a two-tailed unpaired t-test was applied using the Prism software.
The details of materials and other methods are described in the Supplementary Material.
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