2.4. Normative resting-state functional connectivity MRI dataset

The normative rs-fcMRI dataset consisted of 104 healthy participants (41 males, mean age 21.4 ± 2.8 years) who were part of a publicly available dataset (Buckner; Thomas Yeo et al., 2011). The study was conducted with the written consent of each subject and approved by the Partners’ Institutional Review Board. Imaging was performed on a 3 T Siemens whole-body MRI System with a phased-array head coil. Each subject completed two 6.2-min (124 frames) resting-state functional magnetic resonance imaging (fMRI) scans (TR = 3000 ms, TE = 30 ms, FA = 85°, 3 × 3 × 3 mm voxels, FOV = 216, 47 axial slices with interleaved acquisition and no gap). Participants were asked to rest in the scanner with their eyes open. rs-fcMRI data were processed in accordance with the strategy of Fox et al. (Fox et al., 2005) as implemented by Van Dijk et al. (Van Dijk et al., 2010). Structural data, including a high-resolution, multi-echo, T1-weighted, magnetization-prepared, gradient-echo image (TR = 2200 ms, TI = 1100 ms, TE = 1.54 ms for image 1 to 7.01 ms for image 4, FA = 7°, 1.2 × 1.2 × 1.2 mm voxels, FOV = 230), were also downloaded from the same dataset as rs-fc MRI.